CATH Classification

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Transcription initiation factor TFIID subunit

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P21675
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt P21675
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

UniProtKB Entries (1)

Q9Y294
ASF1A_HUMAN
Homo sapiens
Histone chaperone ASF1A

PDB Structure

PDB 3AAD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction
Akai, Y., Adachi, N., Hayashi, Y., Eitoku, M., Sano, N., Natsume, R., Kudo, N., Tanokura, M., Senda, T., Horikoshi, M.
Proc.Natl.Acad.Sci.USA