CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt Q00722
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

Q00722
PLCB2_HUMAN
Homo sapiens
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

PDB Structure

PDB 2ZKM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
General and versatile autoinhibition of PLC isozymes
Hicks, S.N., Jezyk, M.R., Gershburg, S., Seifert, J.P., Harden, T.K., Sondek, J.
Mol.Cell