CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family Type 2 DNA topoisomerase 6 subunit B

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt O05207
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

O05207
TOP6B_SACSH
Saccharolobus shibatae
Type 2 DNA topoisomerase 6 subunit B

PDB Structure

PDB 2ZBK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of an Intact Type II DNA Topoisomerase: Insights into DNA Transfer Mechanisms
Graille, M., Durand, D., Lecointe, F., Gadelle, D., Quevillon-Cheruel, S., Vachette, P., Forterre, P., van Tilbeurgh, H.
Structure