CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.20 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.20 |
| Functional Family |
Enzyme Information
| 6.3.4.18 |
5-(carboxyamino)imidazole ribonucleotide synthase.
based on mapping to UniProt O66608
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
-!- In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates. -!- Carboxyphosphate is the putative acyl phosphate intermediate. -!- Involved in the late stages of purine biosynthesis.
|
UniProtKB Entries (1)
| O66608 |
PURK_AQUAE
Aquifex aeolicus VF5
N5-carboxyaminoimidazole ribonucleotide synthase
|
PDB Structure
| PDB | 2Z04 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit from Aquifex aeolicus
To be Published
|