CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Enzyme Information

3.1.3.86
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
based on mapping to UniProt Q92835
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.
-!- This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. -!- The enzyme also shows activity toward PtdIns(1,3,4,5)P(4). -!- The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. -!- Formerly EC 3.1.3.n1.

UniProtKB Entries (1)

Q92835
SHIP1_HUMAN
Homo sapiens
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

PDB Structure

PDB 2YSX
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the human SHIP SH2 domain
Kasai, T., Koshiba, S., Watanabe, S., Harada, T., Kigawa, T., Yokoyama, S.
To be Published