CATH Classification

Domain Context

CATH Clusters

Superfamily Neutral endopeptidase , domain2
Functional Family Membrane metalloendopeptidase

Enzyme Information

3.4.24.11
Neprilysin.
based on mapping to UniProt P08473
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
-!- A membrane-bound glycoprotein widely distributed in animal tissues. -!- Inhibited by phosphoramidon and thiorphan. -!- Belongs to peptidase family M13.

UniProtKB Entries (1)

P08473
NEP_HUMAN
Homo sapiens
Neprilysin

PDB Structure

PDB 2YB9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Evaluation of Heteroarylalanine Diacids as Potent and Selective Neutral Endopeptidase Inhibitors.
Glossop, M.S., Bazin, R.J., Dack, K.N., Fox, D.N.A., Macdonald, G.A., Mills, M., Owen, D.R., Phillips, C., Reeves, K.A., Ringer, T.J., Strang, R.S., Watson, C.A.L.
Bioorg.Med.Chem.Lett.