CATH Classification

Domain Context

CATH Clusters

Superfamily 2.20.70.100
Functional Family

Enzyme Information

4.1.1.83
4-hydroxyphenylacetate decarboxylase.
based on mapping to UniProt Q38HX3
(4-hydroxyphenyl)acetate = 4-methylphenol + CO(2).
-!- The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product. -!- The enzyme is a glycyl radical enzyme.

UniProtKB Entries (1)

Q38HX4
HPDL_CLOSL
Clostridium scatologenes
4-hydroxyphenylacetate decarboxylase large subunit

PDB Structure

PDB 2YAJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for a Kolbe-Type Decarboxylation Catalyzed by a Glycyl Radical Enzyme.
Martins, B.M., Blaser, M., Feliks, M., Ullmann, G.M., Buckel, W., Selmer, T.
J.Am.Chem.Soc.