CATH Classification

Domain Context

CATH Clusters

Superfamily Copper amine oxidase, catalytic domain
Functional Family Amine oxidase

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt Q16853
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

Q16853
AOC3_HUMAN
Homo sapiens
Membrane primary amine oxidase

PDB Structure

PDB 2Y74
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase Aoc3.
Elovaara, H., Kidron, H., Parkash, V., Nymalm, Y., Bligt, E., Ollikka, P., Smith, D.J., Pihlavisto, M., Salmi, M., Jalkanen, S., Salminen, T.A.
Biochemistry