CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.23
Matrilysin.
based on mapping to UniProt P09237
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
-!- Similar in specificity to stromelysin, but more active on azocoll. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P09237
MMP7_HUMAN
Homo sapiens
Matrilysin

PDB Structure

PDB 2Y6D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Discovery of Mmp7 Inhibitors Exploiting a Novel Selectivity Trigger.
Edman, K., Furber, M., Hemsley, P., Johansson, C., Pairaudeau, G., Petersen, J., Stocks, M., Tervo, A., Ward, A., Wells, E., Wissler, L.
Chemmedchem