CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q6VAB6
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (2)

P29678
MP2K1_RABIT
Oryctolagus cuniculus
Dual specificity mitogen-activated protein kinase kinase 1
Q6VAB6
KSR2_HUMAN
Homo sapiens
Kinase suppressor of Ras 2

PDB Structure

PDB 2Y4I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek
Brennan, D.F., Dar, A.C., Hertz, N.T., Chao, W., Burlingame, A.L., Shokat, K.M., Barford, D.
Nature