CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.20.770
Functional Family phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt Q8BTI9
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

UniProtKB Entries (1)

Q8BTI9
PK3CB_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

PDB Structure

PDB 2Y3A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism.
Zhang, X., Vadas, O., Perisic, O., Anderson, K.E., Clark, J., Hawkins, P.T., Stephens, L.R., Williams, R.L.
Mol.Cell