CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q5SJA1
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q5SJA1
LDH_THET8
Thermus thermophilus HB8
L-lactate dehydrogenase

PDB Structure

PDB 2XXJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Lactate Dehydrogenase from T. Thermophilus, Penta- Mutant (Ternary Complex)
Tickle, J., De Mendoza Barbera, E., Vellieux, F.M.D.
To be Published