CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q5SJA1
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q5SJA1
LDH_THET8
Thermus thermophilus HB8
L-lactate dehydrogenase

PDB Structure

PDB 2XXB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Lactate Dehydrogenase from T. Thermophilus, Penta-Mutant (Complex with AMP)
Diop, F., Coquelle, N., Vellieux, F.M.D.
To be Published