CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family RuvB-like 2

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q9Y230
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q9Y230
RUVB2_HUMAN
Homo sapiens
RuvB-like 2

PDB Structure

PDB 2XSZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Insights Into a Dodecameric Molecular Machine - the Ruvbl1/Ruvbl2 Complex.
Gorynia, S., Bandeiras, T.M., Pinho, F.G., Mcvey, C.E., Vonrhein, C., Round, A., Svergun, D.I., Donner, P., Matias, P.M., Carrondo, M.A.
J.Struct.Biol.