CATH Classification

Domain Context

CATH Clusters

Superfamily SRCR-like domain
Functional Family Complement factor I

Enzyme Information

3.4.21.45
Complement factor I.
based on mapping to UniProt P05156
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
-!- Cleavage of complement subcomponent C3b requires its binding to cofactor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P05156
CFAI_HUMAN
Homo sapiens
Complement factor I

PDB Structure

PDB 2XRC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms.
Roversi, P., Johnson, S., Caesar, J.J., Mclean, F., Leath, K.J., Tsiftsoglou, S.A., Morgan, B.P., Harris, C.L., Sim, R.B., Lea, S.M.
Proc.Natl.Acad.Sci.USA