CATH Classification

Domain Context

CATH Clusters

Superfamily Translation factors
Functional Family Ferredoxin--NADP(+) reductase

Enzyme Information

1.19.1.1
Flavodoxin--NADP(+) reductase.
based on mapping to UniProt P28861
Reduced flavodoxin + NADP(+) = oxidized flavodoxin + NADPH.
-!- This activity occurs in some prokaryotes and algae that possess flavodoxin, and provides low-potential electrons for a variety of reactions such as nitrogen fixation, sulfur assimilation and amino acid biosynthesis. -!- In photosynthetic organisms it is involved in the photosynthetic electron transport chain. -!- The enzyme also catalyzes EC 1.18.1.2.
1.18.1.2
Ferredoxin--NADP(+) reductase.
based on mapping to UniProt P28861
2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH.
-!- In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe- 2S] ferredoxins, but in other bacteria it can also reduce bacterial 2[4Fe-4S] ferredoxins and flavodoxin. -!- Formerly EC 1.6.7.1 and EC 1.6.99.4.

UniProtKB Entries (1)

P28861
FENR_ECOLI
Escherichia coli K-12
Flavodoxin/ferredoxin--NADP reductase

PDB Structure

PDB 2XNJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Swapping Fad Binding Motifs between Plastidic and Bacterial Ferredoxin-Nadp(H) Reductases.
Musumeci, M.A., Botti, H., Buschiazzo, A., Ceccarelli, E.A.
Biochemistry