CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.230.10
Functional Family Lon protease homolog, mitochondrial

Enzyme Information

3.4.21.53
Endopeptidase La.
based on mapping to UniProt P36776
Hydrolysis of proteins in presence of ATP.
-!- ATP hydrolysis is linked with peptide bond hydrolysis. -!- Vanadate inhibits both reactions. -!- A similar enzyme occurs in animal mitochondria. -!- Belongs to peptidase family S16.

UniProtKB Entries (1)

P36776
LONM_HUMAN
Homo sapiens
Lon protease homolog, mitochondrial

PDB Structure

PDB 2X36
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Catalytic Domain of the Human Mitochondrial Lon Protease: Proposed Relation of Oligomer Formation and Activity.
Garcia-Nafria, J., Ondrovicova, G., Blagova, E., Levdikov, V.M., Bauer, J.A., Suzuki, C.K., Kutejova, E., Wilkinson, A.J., Wilson, K.S.
Protein Sci.