1 keywords

CATH Domain 2wweA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1520 PX Domain
Homologous Superfamily 3.30.1520.10 Phox-like domain

Domain Context

CATH Clusters

Superfamily Phox-like domain
Functional Family Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Enzyme Information

2.7.1.154
Phosphatidylinositol-4-phosphate 3-kinase.
based on mapping to UniProt O75747
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate.
-!- This enzyme also phosphorylates PtdIns to PtdIns3P.

UniProtKB Entries (1)

O75747
P3C2G_HUMAN
Homo sapiens
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

PDB Structure

PDB 2WWE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Phox Homology Domain of Human Phosphoinositide-3-Kinase-C2-Gamma
Roos, A.K., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotyenova, T., Kotzch, A., Kraulis, P., Markova, N., Moche, M., Nielsen, T.K., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC)
To be Published