CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 1
Functional Family NAD/NADP-dependent betaine aldehyde dehydrogenase

Enzyme Information

1.2.1.8
Betaine-aldehyde dehydrogenase.
based on mapping to UniProt Q9HTJ1
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
-!- In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. -!- This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria. -!- In contrast, different enzymes are involved in the first reaction. -!- In plants, this reaction is catalyzed by EC 1.14.15.7, whereas in animals and many bacteria, it is catalyzed by either membrane-bound EC 1.1.99.1 or soluble EC 1.1.3.17. -!- In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 and EC 2.1.1.157.

UniProtKB Entries (1)

Q9HTJ1
BETB_PSEAE
Pseudomonas aeruginosa PAO1
NAD/NADP-dependent betaine aldehyde dehydrogenase

PDB Structure

PDB 2WME
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Crystal Structure of a Ternary Complex of Betaine Aldehyde Dehydrogenase from Pseudomonas Aeruginosa Provides New Insight Into the Reaction Mechanism and Shows a Novel Binding Mode of the 2'- Phosphate of Nadp(+) and a Novel Cation Binding Site.
Gonzalez-Segura, L., Rudino-Pinera, E., Munoz-Clares, R.A., Horjales, E.
J.Mol.Biol.