CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family 5-aminolevulinate synthase, erythroid-specific, mitochondrial

Enzyme Information

2.3.1.47
8-amino-7-oxononanoate synthase.
based on mapping to UniProt Q9KM65
Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].
-!- The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis. -!- Pimeloyl-CoA can be used with lower efficiency.
2.3.-.-
Acyltransferases.
based on mapping to UniProt Q9KM65

UniProtKB Entries (1)

Q9KM65
CQSA_VIBCH
Vibrio cholerae O1 biovar El Tor str. N16961
CAI-1 autoinducer synthase

PDB Structure

PDB 2WKA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights Into the Biosynthesis of the Vibrio Cholerae Major Autoinducer Cai-1 from the Crystal Structure of the Plp-Dependent Enzyme Cqsa.
Jahan, N., Potter, J.A., Sheikh, M.A., Botting, C.H., Shirran, S.L., Westwood, N.J., Taylor, G.L.
J.Mol.Biol.