CATH Classification

Domain Context

CATH Clusters

Superfamily Mur ligase, C-terminal domain
Functional Family UDP-N-acetylmuramoylalanine--D-glutamate ligase

Enzyme Information

6.3.2.9
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.
based on mapping to UniProt P14900
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.
-!- Involved in the synthesis of a cell-wall peptide in bacteria.

UniProtKB Entries (1)

P14900
MURD_ECOLI
Escherichia coli K-12
UDP-N-acetylmuramoylalanine--D-glutamate ligase

PDB Structure

PDB 2WJP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Novel 5-Benzylidenerhodanine and 5-Benzylidenethiazolidine-2,4-Dione Inhibitors of Murd Ligase.
Zidar, N., Tomasic, T., Sink, R., Rupnik, V., Kovac, A., Turk, S., Patin, D., Blanot, D., Contreras Martel, C., Dessen, A., Muller Premru, M., Zega, A., Gobec, S., Peterlin Masic, L., Kikelj, D.
J.Med.Chem.