CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cyclin-dependent kinase 4

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P11802
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24385
CCND1_HUMAN
Homo sapiens
G1/S-specific cyclin-D1

PDB Structure

PDB 2W99
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Day, P.J., Cleasby, A., Tickle, I.J., O'Reilly, M., Coyle, J.E., Holding, F.P., Mcmenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Proc.Natl.Acad.Sci.USA