CATH Classification

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, B domain
Functional Family Pyruvate carboxylase subunit A

Enzyme Information

6.3.4.14
Biotin carboxylase.
based on mapping to UniProt P24182
ATP + biotin-[carboxyl-carrier-protein] + HCO(3)(-) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
6.4.1.2
Acetyl-CoA carboxylase.
based on mapping to UniProt P24182
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
-!- Also catalyzes transcarboxylation; the plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA.

UniProtKB Entries (1)

P24182
ACCC_ECOLI
Escherichia coli K-12
Biotin carboxylase

PDB Structure

PDB 2W71
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches.
Mochalkin, I., Miller, J.R., Narasimhan, L.S., Thanabal, V., Erdman, P., Cox, P., Prasad, J.V., Lightle, S., Huband, M., Stover, K.
Acs Chem.Biol.