CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Coagulation factor X

Enzyme Information

3.4.21.6
Coagulation factor Xa.
based on mapping to UniProt P00742
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00742
FA10_HUMAN
Homo sapiens
Coagulation factor X

PDB Structure

PDB 2W3K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Exploration of 4,4-Disubstituted Pyrrolidine-1,2-Dicarboxamides as Potent, Orally Active Factor Xa Inhibitors with Extended Duration of Action.
Van Huis, C.A., Casimiro-Garcia, A., Bigge, C.F., Cody, W.L., Dudley, D.A., Filipski, K.J., Heemstra, R.J., Kohrt, J.T., Leadley, R.J.J., Narasimhan, L.S., Mcclanahan, T., Mochalkin, I., Pamment, M., Peterson, J.T., Sahasrabudhe, V., Schaum, R.P., Edmunds, J.J.
Bioorg.Med.Chem.