CATH Classification

Domain Context

CATH Clusters

Superfamily Hyaluronidase post-catalytic domain-like
Functional Family

Enzyme Information

3.2.1.169
Protein O-GlcNAcase.
based on mapping to UniProt Q89ZI2
(1) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine. (2) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
-!- Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. -!- EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.

UniProtKB Entries (1)

Q89ZI2
OGA_BACTN
Bacteroides thetaiotaomicron VPI-5482
O-GlcNAcase BT_4395

PDB Structure

PDB 2VVN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Potent Mechanism-Inspired O-Glcnacase Inhibitor that Blocks Phosphorylation of Tau in Vivo.
Yuzwa, S.A., Macauley, M.S., Heinonen, J.E., Shan, X., Dennis, R.J., He, Y., Whitworth, G.E., Stubbs, K.A., Mceachern, E.J., Davies, G.J., Vocadlo, D.J.
Nat.Chem.Biol.