CATH Domain 2vg0B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1180	Undecaprenyl pyrophosphate synthetase
	3.40.1180.10	Decaprenyl diphosphate synthase-like

Domain Context

CATH Clusters

Superfamily	Decaprenyl diphosphate synthase-like
Functional Family	Isoprenyl transferase 2

Enzyme Information

2.5.1.68

(2Z,6E)-farnesyl diphosphate synthase.

based on mapping to UniProt P9WFF5

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)- farnesyl diphosphate.

-!- The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. -!- Neryl diphosphate can also act as substrate.

UniProtKB Entries (1)

P9WFF5

ZFPP_MYCTU

Mycobacterium tuberculosis H37Rv

(2Z,6E)-farnesyl diphosphate synthase

PDB Structure

PDB	2VG0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The structural basis of chain length control in Rv1086. Wang, W., Dong, C., McNeil, M., Kaur, D., Mahapatra, S., Crick, D.C., Naismith, J.H. J. Mol. Biol.