CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydropteroate synthase-like
Functional Family Dihydropteroate synthase

Enzyme Information

2.5.1.15
Dihydropteroate synthase.
based on mapping to UniProt P59655
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.
-!- The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). -!- The enzyme exists in varying types of multifunctional proteins in different organisms. -!- The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25.

UniProtKB Entries (1)

P59655
DHPS_STRR6
Streptococcus pneumoniae R6
Dihydropteroate synthase

PDB Structure

PDB 2VEG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dihydropteroate Synthase from Streptococcus Pneumoniae: Structure, Ligand Recognition and Mechanism of Sulfonamide Resistance.
Levy, C., Minnis, D., Derrick, J.
Biochem.J.