CATH Classification

Domain Context

CATH Clusters

Superfamily Zinc finger, large T-antigen D1 domain
Functional Family

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P03116
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P03116
VE1_BPV1
Deltapapillomavirus 4
Replication protein E1

PDB Structure

PDB 2V9P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Papillomavirus E1 Helicase Assembly Maintains an Asymmetric State in the Absence of DNA and Nucleotide Cofactors.
Sanders, C.M., Kovalevskiy, O.V., Sizov, D., Lebedev, A.A., Isupov, M.N., Antson, A.A.
Nucleic Acids Res.