CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q5SJA1
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q5SJA1
LDH_THET8
Thermus thermophilus HB8
L-lactate dehydrogenase

PDB Structure

PDB 2V7P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Activity, stability and structural studies of lactate dehydrogenases adapted to extreme thermal environments.
Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F., Madern, D.
J. Mol. Biol.