CATH Classification

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt O93541
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

O93541
LDHA_CHAGU
Champsocephalus gunnari
L-lactate dehydrogenase A chain

PDB Structure

PDB 2V65
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Activity, Stability and Structural Studies of Lactate Dehydrogenases Adapted to Extreme Thermal Environments.
Coquelle, N., Fioravanti, E., Weik, M., Vellieux, F., Madern, D.
J.Mol.Biol.