CATH Classification

Domain Context

CATH Clusters

Superfamily ligand-binding face of the semaphorins, domain 2
Functional Family

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08581
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (2)

P0DQD2
INLB_LISMO
Listeria monocytogenes EGD-e
Internalin B
P08581
MET_HUMAN
Homo sapiens
Hepatocyte growth factor receptor

PDB Structure

PDB 2UZY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Human Receptor Tyrosine Kinase met in Complex with the Listeria Invasion Protein Inlb
Niemann, H.H., Jager, V., Butler, P.J.G., van den Heuvel, J., Schmidt, S., Ferraris, D., Gherardi, E., Heinz, D.W.
Cell(Cambridge,Mass.)