CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family CTS1p Endochitinase

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P29029
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P29029
CHIT_YEAST
Saccharomyces cerevisiae S288C
Endochitinase

PDB Structure

PDB 2UY4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Saccharomyces Cerevisiae Chitinase 1 and Screening-Based Discovery of Potent Inhibitors.
Hurtado-Guerrero, R., Van Aalten, D.M.F.
Chem.Biol.