CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Tk-subtilisin

Enzyme Information

3.4.21.62
Subtilisin.
based on mapping to UniProt P00782
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
-!- Subtilisin is a serine endopeptidase that evolved independently of chymotrypsin. -!- It contains no cysteine residues (although these are found in homologous enzymes). -!- Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo). -!- Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.4.16 and EC 3.4.21.14.

UniProtKB Entries (1)

P00782
SUBT_BACAM
Bacillus amyloliquefaciens
Subtilisin BPN'

PDB Structure

PDB 2ST1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.
Bott, R., Ultsch, M., Kossiakoff, A., Graycar, T., Katz, B., Power, S.
J.Biol.Chem.