CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.100
Functional Family ATPase copper transporting beta

Enzyme Information

7.2.2.8
P-type Cu(+) transporter.
based on mapping to UniProt P35670
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC 7.2.2.9, which mainly transports the divalent copper ion. -!- Formerly EC 3.6.3.54.

UniProtKB Entries (1)

P35670
ATP7B_HUMAN
Homo sapiens
Copper-transporting ATPase 2

PDB Structure

PDB 2ROP
External Links
Method SOLUTION NMR
Organism
Primary Citation
Metal binding domains 3 and 4 of the Wilson disease protein: solution structure and interaction with the copper(I) chaperone HAH1
Banci, L., Bertini, I., Cantini, F., Rosenzweig, A.C., Yatsunyk, L.A.
Biochemistry