CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.2480
Functional Family

Enzyme Information

2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt O37061
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

O37061
RDRP_ROTSP
Simian 11 rotavirus (serotype 3 / strain SA11-Patton)
RNA-directed RNA polymerase

PDB Structure

PDB 2R7W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1.
Lu, X., McDonald, S.M., Tortorici, M.A., Tao, Y.J., Vasquez-Del Carpio, R., Nibert, M.L., Patton, J.T., Harrison, S.C.
Structure