CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-glycerophosphate oxidase, cap domain
Functional Family Glycerol-3-phosphate dehydrogenase

Enzyme Information

1.1.5.3
Glycerol-3-phosphate dehydrogenase.
based on mapping to UniProt P13035
sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
-!- An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis. -!- In bacteria, the enzyme is localized to the cytoplasmic membrane, while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane. -!- In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8 forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD(+) by the mitochondrial electron-transport chain. -!- This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix. -!- Insect flight muscle uses only CoQ(10) as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ(9). -!- The enzyme is activated by calcium. -!- Formerly EC 1.1.2.1 and EC 1.1.99.5.

UniProtKB Entries (1)

P13035
GLPD_ECOLI
Escherichia coli K-12
Aerobic glycerol-3-phosphate dehydrogenase

PDB Structure

PDB 2R45
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism
Yeh, J.I., Chinte, U., Du, S.
Proc.Natl.Acad.Sci.USA