CATH Classification

Domain Context

CATH Clusters

Superfamily Butyryl-CoA Dehydrogenase, subunit A, domain 3
Functional Family Glutaryl-CoA dehydrogenase, mitochondrial

Enzyme Information

1.3.8.6
Glutaryl-CoA dehydrogenase (ETF).
based on mapping to UniProt Q92947
Glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO(2) + reduced electron-transfer flavoprotein.
-!- The enzyme catalyzes the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 7.2.4.5). -!- FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. -!- The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyzes the oxidation to glutaconyl-CoA (EC 1.3.99.32). -!- Formerly EC 1.3.99.7.

UniProtKB Entries (1)

Q92947
GCDH_HUMAN
Homo sapiens
Glutaryl-CoA dehydrogenase, mitochondrial

PDB Structure

PDB 2R0M
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The effect of a Glu370Asp mutation in glutaryl-CoA dehydrogenase on proton transfer to the dienolate intermediate.
Rao, K.S., Fu, Z., Albro, M., Narayanan, B., Baddam, S., Lee, H.J., Kim, J.J., Frerman, F.E.
Biochemistry