CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Kallikrein related peptidase 11

Enzyme Information

3.4.21.117
Stratum corneum chymotryptic enzyme.
based on mapping to UniProt P49862
Cleavage of proteins with aromatic side chains in the P1 position.
-!- This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. -!- It cleaves the B chain of bovine insulin at 6-Leu-|-Cya-7 (cysteic acid), 16-Tyr-|-Leu-17, 25-Phe-|-Tyr-26 and 26-Tyr-|-Thr-27. -!- It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

P49862
KLK7_HUMAN
Homo sapiens
Kallikrein-7

PDB Structure

PDB 2QXG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7.
Debela, M., Hess, P., Magdolen, V., Schechter, N.M., Steiner, T., Huber, R., Bode, W., Goettig, P.
Proc.Natl.Acad.Sci.Usa