CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
Functional Family NADPH--cytochrome P450 reductase

Enzyme Information

1.16.1.8
[Methionine synthase] reductase.
based on mapping to UniProt Q9UBK8
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosylhomocysteine + NADP(+) = 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L- methionine.
-!- The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13. -!- Electrons are transferred from NADPH to FAD to FMN. -!- Formerly EC 2.1.1.135.

UniProtKB Entries (1)

Q9UBK8
MTRR_HUMAN
Homo sapiens
Methionine synthase reductase

PDB Structure

PDB 2QTL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry
Wolthers, K.R., Lou, X., Toogood, H.S., Leys, D., Scrutton, N.S.
Biochemistry