CATH Classification

Domain Context

CATH Clusters

Superfamily Udp N-acetylglucosamine O-acyltransferase, C-terminal domain
Functional Family Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Enzyme Information

2.3.1.129
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase.
based on mapping to UniProt P0A722
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D- glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)- N-acetyl-alpha-D-glucosamine.
-!- Involved with EC 2.4.1.182 and EC 2.7.1.130 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

UniProtKB Entries (1)

P0A722
LPXA_ECOLI
Escherichia coli K-12
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

PDB Structure

PDB 2QIV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Williams, A.H., Raetz, C.R.H.
Proc.Natl.Acad.Sci.Usa