CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1400
Functional Family Ferrochelatase

Enzyme Information

4.99.1.1
Protoporphyrin ferrochelatase.
based on mapping to UniProt P22830
Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
-!- The enzyme catalyzes the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria.

UniProtKB Entries (1)

P22830
HEMH_HUMAN
Homo sapiens
Ferrochelatase, mitochondrial

PDB Structure

PDB 2QD4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
Medlock, A.E., Dailey, T.A., Ross, T.A., Dailey, H.A., Lanzilotta, W.N.
J.Mol.Biol.