CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family Type 2 DNA topoisomerase 6 subunit B

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt Q8PUB8
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

Q8PUB7
TOP6A_METMA
Methanosarcina mazei Go1
Type 2 DNA topoisomerase 6 subunit A

PDB Structure

PDB 2Q2E
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI
Corbett, K.D., Benedetti, P., Berger, J.M.
Nat.Struct.Mol.Biol.