CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Beta-lactamase

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P00811
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P00811
AMPC_ECOLI
Escherichia coli K-12
Beta-lactamase

PDB Structure

PDB 2PU4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
Babaoglu, K., Simeonov, A., Irwin, J.J., Nelson, M.E., Feng, B., Thomas, C.J., Cancian, L., Costi, M.P., Maltby, D.A., Jadhav, A., Inglese, J., Austin, C.P., Shoichet, B.K.
J.Med.Chem.