CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (C-terminal domain)
Functional Family Adenylosuccinate lyase

Enzyme Information

4.3.2.2
Adenylosuccinate lyase.
based on mapping to UniProt P0AB89
(1) N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP. (2) (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
-!- Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5- aminoimidazole.

UniProtKB Entries (1)

P0AB89
PUR8_ECOLI
Escherichia coli K-12
Adenylosuccinate lyase

PDB Structure

PDB 2PTQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Substrate and Product Complexes of Escherichia coli Adenylosuccinate Lyase Provide New Insights into the Enzymatic Mechanism.
Tsai, M., Koo, J., Yip, P., Colman, R.F., Segall, M.L., Howell, P.L.
J.Mol.Biol.