CATH Classification

Domain Context

CATH Clusters

Superfamily Enolase-like, N-terminal domain
Functional Family L-talarate/galactarate dehydratase

Enzyme Information

4.2.1.156
L-talarate dehydratase.
based on mapping to UniProt Q8ZL58
L-altarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O.
-!- The enzyme, isolated from the bacteria Salmonella typhimurium and Polaromonas sp. JS666, also has activity with galactarate (cf. EC 4.2.1.42).
4.2.1.42
Galactarate dehydratase.
based on mapping to UniProt Q8ZL58
Galactarate = (2R,3S)-2,3-dihydroxy-5-oxohexanedioate + H(2)O.
-!- The enzyme from the bacterium Escherichia coli is specific for galactarate, while the enzyme from Salmonella typhimurium also has activity with L-talarate (cf. EC 4.2.1.156). -!- Cf. EC 4.2.1.158.

UniProtKB Entries (1)

Q8ZL58
TAGAD_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
L-talarate/galactarate dehydratase

PDB Structure

PDB 2PP0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2.
Yew, W.S., Fedorov, A.A., Fedorov, E.V., Almo, S.C., Gerlt, J.A.
Biochemistry