CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.10 Ribbon
Topology 2.10.60 CD59
Homologous Superfamily 2.10.60.10 CD59

Domain Context

CATH Clusters

Superfamily CD59
Functional Family Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P36897
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P36897
TGFR1_HUMAN
Homo sapiens
TGF-beta receptor type-1

PDB Structure

PDB 2PJY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
Groppe, J., Hinck, C.S., Samavarchi-Tehrani, P., Zubieta, C., Schuermann, J.P., Taylor, A.B., Schwarz, P.M., Wrana, J.L., Hinck, A.P.
Mol.Cell