CATH Domain 2p27A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1000	HAD superfamily/HAD-like

Domain Context

CATH Clusters

Superfamily	HAD superfamily/HAD-like
Functional Family	Pyridoxal phosphate phosphatase

Enzyme Information

3.1.3.3

Phosphoserine phosphatase.

based on mapping to UniProt Q96GD0

O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.

3.1.3.74

Pyridoxal phosphatase.

based on mapping to UniProt Q96GD0

Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate.

-!- Specific for phosphorylated vitamin B(6) compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate. -!- This reaction can also be carried out by EC 3.1.3.1 and EC 3.1.3.2, but these enzymes have very broad substrate specificities.

UniProtKB Entries (1)

Q96GD0

PLPP_HUMAN

Homo sapiens

Pyridoxal phosphate phosphatase

PDB Structure

PDB	2P27
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural genomics of protein phosphatases. Almo, S.C., Bonanno, J.B., Sauder, J.M., Emtage, S., Dilorenzo, T.P., Malashkevich, V., Wasserman, S.R., Swaminathan, S., Eswaramoorthy, S., Agarwal, R., Kumaran, D., Madegowda, M., Ragumani, S., Patskovsky, Y., Alvarado, J., Ramagopal, U.A., Faber-Barata, J., Chance, M.R., Sali, A., Fiser, A., Zhang, Z.Y., Lawrence, D.S., Burley, S.K. J.Struct.Funct.Genom.