CATH Classification

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family Pyrimidine/purine nucleoside phosphorylase

Enzyme Information

2.4.2.3
Uridine phosphorylase.
based on mapping to UniProt Q87K41
Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
-!- The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. -!- The mammalian enzyme also accepts 2'-deoxyuridine. -!- Formerly EC 2.4.2.23.
2.4.2.15
Guanosine phosphorylase.
based on mapping to UniProt Q87K41
Guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate.
-!- Also acts on deoxyguanosine.
2.4.2.2
Pyrimidine-nucleoside phosphorylase.
based on mapping to UniProt Q87K41
(1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- Unlike EC 2.4.2.3 and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. -!- The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction. -!- Formerly EC 2.4.2.23.
2.4.2.4
Thymidine phosphorylase.
based on mapping to UniProt Q87K41
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

Q87K41
PPNP_VIBPA
Vibrio parahaemolyticus RIMD 2210633
Pyrimidine/purine nucleoside phosphorylase

PDB Structure

PDB 2OYZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of unknown function protein VPA0057 from Vibrio parahaemolyticus
Chang, C., Volkart, L., Abdullah, J., Joachimiak, A.
To be Published