CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt P05979
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

P05979
PGH1_SHEEP
Ovis aries
Prostaglandin G/H synthase 1

PDB Structure

PDB 2OYU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.
Harman, C.A., Turman, M.V., Kozak, K.R., Marnett, L.J., Smith, W.L., Garavito, R.M.
J.Biol.Chem.