CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00918
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918
CAH2_HUMAN
Homo sapiens
Carbonic anhydrase 2

PDB Structure

PDB 2OSF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
Barrese, A.A., Genis, C., Fisher, S.Z., Orwenyo, J.N., Kumara, M.T., Dutta, S.K., Phillips, E., Kiddle, J.J., Tu, C., Silverman, D.N., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Tripp, B.C.
Biochemistry